教育背景：南京师范大学（博士）
邮箱：yht193525@163.com
研究方向：(1)纳米抗体靶向性药物（如免疫药物、核酸药物、疫苗或细胞药物）递送系统用于肿瘤免疫治疗、抗菌、糖尿病伤口感染、肝-肾-肠等炎症疾病治疗的应用研究；(2)中草药衍生植物外泌体对防治肝肾代谢疾病体系的药理机制研究及药物研发；(3)多功能中药自组装药物的构建及其肝肾疾病治疗应用与机理研究；(4)中药及天然产物的药物靶标及抗炎作用机理
科研成果简介（近5年）
项目：
1.国家自然科学基金-青年基金项目：工程化细菌外膜囊泡生物杂化材料介导的声动力免疫治疗激活cGAS-STING通路增强抗肿瘤免疫机制的研究, 22407049，2025.01- 2027.12, 30万元，在研，主持。
2.广东省基础研究区域联合-青年基金项目：基于工程化细菌外膜囊泡/共轭聚合物生物杂交材料的多管道协同治疗策略用于肿瘤治疗研究, 2022A1515110745，2022.10-2025.9, 10万元，在研，主持。
3.中国博士后科学基金项目：纳米抗体工程化细菌/光热纳米酶生物杂化材料的多管道协同治疗策略用于三阴性乳腺癌治疗研究，2022M712190，2022.06起, 8万元，在研，主持。
4.国家自然科学基金-面上项目：纳米抗体工程化细菌外膜囊泡联合光免疫制剂激活cGAS-STING通路诱导大肠癌抗肿瘤免疫的机制研究, 82373775, 2024.01-2027.12, 49万元，在研，参与。
文章代表作：
（1）Haitao Yuan#; Chong Qiu#; Xiaoxian Wang#;Peili Wang#; Letai Yi; Xin Peng; Xiaolong Xu; Wei Huang; Yunmeng Bai; Jinxi Wei; Jingbo Ma; Yin Kwan Wong; Chunjin Fu; Wei Xiao*; Chunbo Chen*; Ying Long*; Zhijie Li*; Jigang Wang*; Engineering Semiconducting Polymeric Nanoagonists Potentiate cGAS-STING Pathway Activation and Elicit Long Term Memory against Recurrence in Breast Cancer. Adv. Mater. 2024, 2406662 (IF: 27.4)
（2）Haitao Yuan#; Xiaoxian Wang#; Xin Sun#, Di Gu#, Jinan Guo#, Wei Huang , Jingbo Ma , Chunjin Fu , Da Yin *, Guohua Zeng *, Ying Long *, Jigang Wang*, Zhijie Li *; A Photodynamic Nanohybrid System Reverses Hypoxia and Augment Anti-primary and Metastatic Tumor Efficacy of Immunotherapy. Acta Pharm. Sin. B 2025. (DOI:10.1016/j.apsb.2025.04.007, IF: 14.7)
（3）Huanxiang Yuan; Zelin Li; Shaochuan Jia; Ting Wang; Li Xu*;Haitao Yuan*（共同通讯）; Shengliang Li*; Molecular Evolution of Acceptor-Donor-Acceptor-type Conjugated Oligomer Nanoparticles for Efficient Photothermal Antimicrobial Therapy. Adv. Funct. Mater. 2023, 2213209. (IF: 19.924)
（4）Peng Xia#;Haitao Yuan#（共同一作）; Ming Tian#; Tianyu Zhong; Rui Hou; Xiaolong Xu; Jingbo Ma; Huifang Wang; Zhifen Li; Defa Huang; Chengming Qu; Lingyun Dai; Chengchao Xu; Chuanbin Yang; Haibo Jiang; Yuanqiao He; Felix Rückert; Zhijie Li*; Yufeng Yuan*; Jigang Wang*; Surface-Engineered Extracellular Vesicles with CDH17 Nanobodies to Efficiently Deliver Imaging Probes and Chemo-Photothermal Drugs for Gastric Cancer Theragnostic. Adv. Funct. Mater. 2022, 2209393 (IF: 19.924)
（5）Haitao Yuan#; Yunmeng Bai#; Di Gu#; Peili Wang#; Xin Sun#; Jing Yang; Yin Kwan Wong; Wei Huang; Xiaoxian Wang; Jingbo Ma; Zhiyu Dong; Ruixing Chen; Jiexuan Li; Zhijie Li*; Guohua Zeng*; Zipeng Gong*; Chuanbin Yang*; Jigang Wang*; Deciphering Single-cell Transcriptomic Landscape of Tumors in Colorectal Cancer Treated with Photothermal Semiconducting Polymers to Design the Combination Therapy with Checkpoint Blockades for Inhibition of Tumor Progression and Metastasis. Nano Today 2024, 58,102419. (IF: 18.9)
（6）Chengming Qu#;Haitao Yuan#（共同一作）; Ming Tian#; Xiaodong Zhang#; Peng Xia; Guangwei Shi; Rui Hou; Ji Li; Haibo Jiang; Zhiyong Yang; Tengxiang Chen; Zhijie Li; Jigang Wang*; Yufeng Yuan*; Precise Photodynamic Therapy by Midkine Nanobody-Engineered Nanoparticles Remodels the Microenvironment of Pancreatic Ductal Adenocarcinoma and Potentiates the Immunotherapy. ACS Nano 2024, 18, 4019−4037 (IF: 18)
（7）Haitao Yuan#; Peng Xia#; Xin Sun#; Jingbo Ma; Xiaolong Xu; Chunjin Fu; Hongchao Zhou; Yudong Guan; Zhifen Li; Shanshan Zhao; Huifang Wang; Lingyun Dai; Chengchao Xu; Shaohong Dong*; Qingshan Geng*; Zhijie Li*; Jigang Wang*; Photothermal Nanozymatic Nanoparticles Induce Ferroptosis and Apoptosis through Tumor Microenvironment Manipulation for Cancer Therapy. Small 2022, 18, 2202161. (IF: 15.153)
（8）Haitao Yuan#; Xiaoping Hong#; Huan Ma#; Chunjin Fu#; Yudong Guan; Wei Huang; Jingbo Ma; Peng Xia; Min Cao; Liuhai Zheng; Xiaolong Xu; Chengchao Xu; Dongzhou Liu*; Zhijie Li*; Qingshan Geng*; Jigang Wang*; MXene-Based Dual Functional Nanocomposite with Photothermal Nanozyme Catalytic Activity to Fight Bacterial Infections. ACS Mater. Lett. 2023, 5, 762-774 (IF: 11.4)
（9）Haitao Yuan#; Fujing Wang#; Zhen Wang#; Di Gu#; Wei Huang; Chunjin Fu; Xiaoxian Wang; Jingbo Ma; Zhijie Li; Lingyun Dai; Xinzhou Zhang*; Wei Xiao*; Jigang Wang*, Natural Metal Polyphenol Nanozyme: Scavenging Free Radicals and Antioxidation for Acute Kidney Injury treatment. ACS Mater. Lett. 2023, 5, 2807−2819 (IF: 11.4)
（10）Haitao Yuan#; Jingbo Ma#; Wei Huang#; Ping Gong#; Fei Shi#; Xiaolong Xu; Chunjin Fu; Xiaoxian Wang; Yin Kwan Wong; Ying Long; Xin Sun*; Weihua Li*; Zhijie Li*; Jigang Wang*; Anti-Tumor Effects of a Distinct Sonodynamic Nanosystem through enhanced Induction of Immunogenic Cell Death and Ferroptosis with Modulation of Tumor Microenvironment. JACS Au 2023, 3, 5, 1507–1520 (IF: 8.5)
