教育背景：中山大学（博士）

邮箱：zhangshangshi@gdpu.edu.cn

研究方向：

1. 新型类卡拜等同试剂的设计、合成与反应性研究。

2. 过渡金属催化烯基氧化锍叶立德、氧化锍叶立德、氧化锍叶立德三价碘底物的环化、串联、插入反应研究。

3. 药物分子及生物活性分子的设计、合成与修饰及其抗肿瘤活性研究。

4. 药物分子关键中间体的合成工艺开发及精细化工产品的开发与研究。

5. 第九族Cp*M(III)催化的C-H键官能化反应运用于活性分子骨架构建的合成方法学研究。

科研成果简介（近5年）

项目：

1. 国家自然科学基金青年项目，22001044，基于新型烯基氧化锍叶立德的[4+3]环加成反应用于七元碳环骨架构建的研究，2021.01-2023.12，主持

2. 广东省普通高校特色创新项目（自然科学类），51377201，有机合成新策略在小分子碲化合物合成中的应用，2019.05-2022.04，主持

3. 广州市基础研究计划基础与应用基础研究项目，2023A04J0691，烯基氧化锍叶立德的精准活化策略用于五-七元全碳环骨架构建的反应研究，2023.04-2025.03，主持

4. 广东药科大学-东莞清溪医院联合培育科研基金项目，靶向Top1/c-myc G-四链体的新型抗癌先导化合物的发现与作用机制研究，2025.05-2028.04，主持

文章：

1. Shang-Shi Zhang*, Jiaohang Wei, Qiong Hu, Zi-Feng Yang, Wen-Xuan Zou, Dan-Ting Shen, Mei-Zhu Bao, Xiang Liu*. Divergent Construction of α,α-Difunctionalized Ketones via [1,2]-Sigmatropic Rearrangement/Alkylation-Hydroxylation/Dialkylation of I(III)/S(VI) Ylides. Org. Lett. 2025, 27, 3709-3714.

2. Dan-Ting Shen, Wen-Rong Wu, Wen-Xuan Zou, Qiong Hu, Jiaohang Wei, Mei-Zhu Bao, Xiang Liu* and Shang-Shi Zhang*. Isocyanide-Based Multicomponent Reaction: Cascade α‑Acyloxylation/Carboxamidation and [3 + 1+1] Cyclization of I(III)/S(VI)-Ylides. Org. Lett. 2024, 26, 6263-6268.

3. Wen-Xuan Zou, Qiong Hu, Dan-Ting Shen, Wen-Rong Wu, Jiaohang Wei, Zi-Feng Yang, Mei-Zhu Bao, Xiang Liu* and Shang-Shi Zhang*. A Platform for the Synthesis of Diverse Phosphonyl and Thiofunctionalized Sulfoxonium Ylides. Org. Lett. 2024, 26, 5811-5816.

4. Lin Xiao, Xu-Ge Liu*, Mei-Zhu Bao, Jia-Lin Song, Shao-Yong Chen, Yi-Chuan Zheng, Yan-Zhi Liu, and Shang-Shi Zhang*. Cp*Rh(III)-Catalyzed ortho-Alkylation/Alkenylation of Nitroarenes. Org. Lett. 2023, 25, 5185-5190.

5. Yan-Zhi Liu, Yao-Fu Zeng* Jiaohang Wei, Lin Xiao, Bing Shu, Jia-Lin Song, Wen-Xuan Zou, Dan-Ting Shen, Shao-Yong Chen, Yi-Chuan Zheng, and Shang-Shi Zhang*. Rh(III)-Catalyzed Dienylation and Cyclopropylation of 1,2,3-Benzotriazinones with Alkylidenecyclopropanes. Org. Lett. 2023, 25, 5179-5184.

6. Shao-Yong Chen, Yao-Fu Zeng, Wen-Xuan Zou, Dan-Ting Shen, Yi-Chuan Zheng, Jia-Lin Song, and Shang-Shi Zhang*, Divergent Synthesis of Tetrasubstituted Phenols via [3+3] Cycloaddition Reaction of Vinyl Sulfoxonnium Ylides with Cyclopropenones. Org. Lett. 2023, 25, 4286-4291.

7. Yi-Chuan Zheng, Bing Shu, Yao-Fu Zeng, Shao-Yong Chen, Jia-Lin Song, Yan-Zhi Liu, Lin Xiao, Xu-Ge Liu,* Xuanxuan Zhang* and Shang-Shi Zhang*, A cascade indazolone-directed Ir(iii)- and Rh(iii)-catalyzed C(sp2)-H functionalization/[4+2] annulation of 1-arylindazolones with sulfoxonium ylides to access chemically divergent 8H-indazolo [1,2-a]cinnolines. Org. Chem. Front., 2022, 9, 5185-5190.

8. Shang-Shi Zhang*, Yi-Chuan Zheng, Zi-Wu Zhang, Shao-Yong Chen, Hui Xie, Bing Shu,      Jia-Lin Song, Yan-Zhi Liu, Yao-Fu Zeng*, and Luyong Zhang*, Access to Branched Allylarenes via Rhodium(III)-Catalyzed C-H Allylation of (Hetero)arenes with 2-Methylidenetrimethylene Carbonate. Org. Lett. 2021, 23, 5719-5723.

9. Bing Shu, Xiao-Tong Wang,, Zi-Xuan Shen, Tong Che, Mei Zhong, Jia-Lin Song, Hua-Jie Kang, Hui Xie, luyong Zhang,* Shang-Shi Zhang*, Iridium-Catalyzed Arylation of Sulfoxonium Ylides and Arylboronic Acid: A Straightforward Preparation of α-Aryl Ketones. (co-first author) Org. Chem. Front., 2020, 7, 1802-1808.